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Product Name Anti-MMP21/APC Chinese Name APC标记的基质金属蛋白酶21抗体 Alias Matrix metalloproteinase 21; MIFR; MMP21_HUMAN; MMP 21. Research Area Tumour Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Horse, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 49kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MMP21 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]
Function:
May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin.
Subcellular Location:
Secreted
Tissue Specificity:
Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase
Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin repeats.
Database links:Entrez Gene: 118856 Human
Entrez Gene: 214766 Mouse
Omim: 608416 Human
SwissProt: Q8N119 Human
SwissProt: Q8K3F2 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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