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Product Name Anti-LRP3/APC Chinese Name APC标记的低密度Lipoprotein受体相关蛋白3抗体 Alias 105 kDa low-density lipoprotein receptor-related protein; hLRp105; Low density lipoprotein receptor related protein 3; Low-density lipoprotein receptor-related protein 3; LRP-3; Lrp3; LRP3_HUMAN. Research Area Tumour Cell biology Signal transduction The cell membrane受体 The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 79kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LRP3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Low-density lipoprotein receptor-related protein 3 (LRP3) is a 770 amino acid protein that contains two CUB domains and four LDL-receptor class A domains. LRP3 is widely expressed with highest expression in skeletal muscle and ovary and lowest expression in testis, colon and leukocytes. LRP3 is potentially a membrane receptor involved in the internalization of lipophilic molecules and/or signal transduction.
Function:
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
Subcellular Location:
Membrane. Membrane > coated pit.Target information above from: UniProt accession O75074 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res. 38:D142-D148 (2010) .
Tissue Specificity:
Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.
Similarity:
Belongs to the LDLR family.
Contains 2 CUB domains.
Contains 4 LDL-receptor class A domains.
Database links:Entrez Gene: 4037 Human
Entrez Gene: 435965 Mouse
Omim: 603159 Human
SwissProt: O75074 Human
Unigene: 515340 Human
Unigene: 273631 Mouse
Unigene: 145216 Rat
Unigene: 87059 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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