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Product Name Anti-TNRC5/PRAT4A/APC Chinese Name APC标记的Toll样受体4相关蛋白抗体 Alias CAG repeat containing; CAG4A; Canopy 3 homolog; cnpy3; CNPY3_HUMAN; CTG repeat protein 4a; ERDA 5; ERDA5; Expanded repeat domain CAG/CTG 5; Expanded repeat-domain protein CAG/CTG 5; OTTHUMP00000016408; PRAT4A; Protein associated with Tlr4; Protein associated with Toll like receptor 4A; Protein canopy homolog 3; TNRC 5; Trinucleotide repeat containing 5; Trinucleotide repeat-containing gene 5 protein. Research Area Cell biology immunology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 31kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TNRC5/PRAT4A Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
PRAT4A is associated with the immature form of TLR4 (MIM 603030) and regulates its cell surface expression (Wakabayashi et al., 2006 [PubMed 16849487]).[supplied by OMIM, Mar 2008]
Function:
Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses.
Subcellular Location:
Endoplasmic reticulum.
Similarity:
Belongs to the canopy family.
Contains 1 saposin B-type domain.
Database links:Entrez Gene: 10695 Human
Omim: 610774 Human
SwissProt: Q9BT09 Human
Unigene: 414099 Human
Unigene: 43984 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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