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Product Name Anti-Speedy protein C/APC Chinese Name APC标记的快速周期蛋白C抗体 Alias hSpy/Ringo C; Rapid inducer of G2/M progression in oocytes C; Rapid inducer of G2/M progression in oocytes, Xenopus, homolog of, C; RINGO C; Ringo2; SPDYC; SPDYC_HUMAN; speedy C; speedy homolog C; Speedy protein C; Speedy, Xenopus, homolog of, C. Research Area Cell biology Cyclin Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 33kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Speedy protein C Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2.
Function:
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correctlocalization of the active form of Aurora B in prometaphase.
Subunit:
Interacts with CDK1 and CDK2. Interacts with AURKB.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis.
DISEASE:
Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis.
Similarity:
Belongs to the Speedy/Ringo family.
Database links:Entrez Gene: 387778 Human
Omim: 614030 Human
SwissProt: Q5MJ68 Human
Unigene: 450642 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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