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Product Name Anti-GSH2/APC Chinese Name APC标记的GSH2蛋白抗体 Alias GS homeobox 2; GSX2; GSX2_HUMAN; Homeobox protein GSH 2; Homeobox protein GSH-2. Research Area Cell biology Transporter Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 32kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GSH2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure. The homeobox DNA-binding domain is commonly found in proteins that play a role in development and are involved in transcriptional regulation and the control of gene expression. GSH-2 (GS homeobox-2), also known as GSX2, is a 304 amino acid protein that contains one homeobox DNA-binding domain. Localized to the nucleus, GSH-2 is thought to function as a transcription factor that selectively binds the DNA sequence 5'-CNAATTAG-3'. Specifically, GSH-2 may be involved in neuronal differentiation, playing a role in spinal cord development.
Function:
Probable transcription factor that binds to the DNA sequence 5'-CNAATTAG-3' (By similarity).
Subcellular Location:
Nucleus (By similarity).
Similarity:
Belongs to the Antp homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:Entrez Gene: 170825 Human
Entrez Gene: 14843 Mouse
SwissProt: Q9BZM3 Human
SwissProt: P31316 Mouse
Unigene: 371899 Human
Unigene: 218752 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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