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Product Name Anti-FBG4/APC Chinese Name APC标记的FBG4蛋白抗体 Alias F box only protein 17; F box only protein 26; F-box only protein 17; F-box only protein 26; F-box protein 17; F-box protein FBG4; FBX17; FBX17_HUMAN; FBX26; Fbxo17; FBXO26; FLJ11798; FLJ25205; FLJ58300; MGC9379. Research Area Cell biology immunology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 31kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FBG4 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.
Tissue Specificity:
Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.
Similarity:
Contains 1 F-box domain.
Contains 1 FBA (F-box associated) domain.
Database links:Entrez Gene: 115290 Human
Entrez Gene: 50760 Mouse
GenBank: NM_024907 Human
GenBank: NM_148169 Human
GenBank: NM_015796 Mouse
Omim: 609094 Human
SwissProt: Q96EF6 Human
SwissProt: Q9QZM8 Mouse
Unigene: 531770 Human
Unigene: 358659 Mouse
Unigene: 53606 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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