Product Name	Anti-phospho-ZFP36L1 (Ser92)/APC
Chinese Name	APC标记的磷酸化丁酸盐反应因子1抗体
Alias	butyrate response factor 1 (phospho S92); ZFP36L1 (phospho S92); Berg36; BRF1; Butyrate response factor 1(phospho S334); C3H1 type-like 1; cMG1; Early response factor Berg36; EGF response factor 1; EGF-response factor 1; ERF 1; ERF-1; ERF1; Protein TIS11B; RNF162B; TIS11B; TISB_HUMAN; ZFP36L1; Zinc finger protein 36 C3H type like 1; zinc finger protein C3H type 36 like 1; BERG36; Zinc finger protein 36, C3H1 type-like 1.
Product Type	Phosphorylated anti
Research Area	Cell biology  Developmental biology  Signal transduction  Stem cells  Growth factors and hormones  transcriptional regulatory factor  Zinc finger protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	36kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from human butyrate response factor 1 around the phosphorylation site of Ser92 [SF(p-S)EG]
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: EGF response factor 1 is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. TIS11B, a relative of TTP, localizes to the nucleus and may function as a transcription factor involved in regulating the growth factor response. It is an evolutionarily conserved protein containing two C3H1-type zinc fingers and a repeating cys-his motif. TIS11B is an mRNA binding protein and is known to interact with the 3’-untranslated region of VEGF mRNA, thereby decreasing its stability. This suggests that TIS11B is a potential target in antiangiogenic therapy. In addition, TIS11B may also be an important regulator of myogenesis, as its expression is upregulated during murine myoblast differentiation. Function: Butyrate response factor 1 is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating Cys-His motif. This putative nuclear transcription factor probably functions in regulating the response to growth factors. Subcellular Location: Nuclear. Similarity: Contains 2 C3H1-type zinc fingers. Database links: Entrez Gene: 400223 Human Entrez Gene: 677 Human Entrez Gene: 12192 Mouse Entrez Gene: 29344 Rat Omim: 601064 Human SwissProt: Q07352 Human SwissProt: P23950 Mouse SwissProt: P17431 Rat Unigene: 707091 Human Unigene: 85155 Human Unigene: 235132 Mouse Unigene: 6142 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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