Product Name	Anti-IGFBP4/APC
Chinese Name	APC标记的胰岛素样生长因子Binding protein4抗体
Alias	Insulin-like Growth Factor Binding Protein 4; BP 4; BP4; HT29 IGFBP; IBP 4; IBP4; IGF binding protein 4; IGFBP 4; IBP4_HUMAN.
Research Area	Tumour  immunology  Growth factors and hormones  transcriptional regulatory factor  Diabetes
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Pig, Cow, Horse, Sheep, )
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	26kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IGFBP4
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Insulin like growth factor binding protein 4 (IGFBP4) is produced from a DNA sequence encoding the human IGFBP4 protein. Mature human IGFBP4 has a calculated molecular mass of approximately 26 kDa. Due to glycosylation, the recombinant protein migrates as a 32 kDa and 25 kDa protein under reducing and non reducing conditions, respectively. Human IGFBP4 has a potential N-linked glycosylation site and shares approximately 90% amino acid sequence identity with both mouse and rat IGFBP4. IGFBP4 is a member of the superfamily of insulin-like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). IGFBP4 functions as an inhibitor of IGF action and its main function may be to protect cells from overstimulation by IGFs or to allow activation of alternate transmembrane signaling pathways that are inhibited by IGF exposure. IGFBP4 is expressed in multiple tissues including adrenal, testis, spleen, heart, lung, kidney, liver, stomach, hypothalamus, and brain cortex. Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Subunit: Binds IGF2 more than IGF1. Subcellular Location: Secreted. Similarity: Contains 1 IGFBP N-terminal domain. Contains 1 thyroglobulin type-1 domain. Database links: Entrez Gene: 374271 Chicken Entrez Gene: 282262 Cow Entrez Gene: 3487 Human Entrez Gene: 16010 Mouse Entrez Gene: 360622 Rat Entrez Gene: 443470 Sheep Omim: 146733 Human SwissProt: Q05716 Cow SwissProt: P22692 Human SwissProt: P47879 Mouse SwissProt: P24854 Pig SwissProt: P21744 Rat SwissProt: Q28893 Sheep Unigene: 462998 Human Unigene: 233799 Mouse Unigene: 160666 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Growth factors and hormones（ Growth Factor and Hormones） IGFBP5胰岛素样生长因子Binding protein4(IGFBP-4)是一种可以与胰岛素样生长因子(IGFs)结合的分泌性蛋白,其通过IGFs调节细胞的生长、分化、凋亡、黏附和运动,IGFBP-4与IGFs结合可以调节IGFs与IGF-I型受体间的相互作用,改变其促有丝分裂效应、凋亡抑制效应和促细胞运动作用.

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