Product Name	Anti-HDAC11/APC
Chinese Name	APC标记的组蛋白去乙酰化酶11抗体
Alias	HD 11; HD11; HDAC 11; Histone deacetylase 11; FLJ22237; HDA11_HUMAN.
Research Area	Tumour  immunology  Signal transduction  Apoptosis  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Pig, Horse, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	39kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HDAC11
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Histone deacetylases (HDAC) are a family of 11 enzymes that are involved in the regulation of gene activation and silencing by regulating chromatin structure. HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Deacetylation of histones is associated with the condensation of chromatin to a compact structure (heterochromatin) in which the genes are silenced. Each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo. HDACs are known to be associated with a number of well characterized cellular oncogenes and tumour- suppressor genes and inhibitors of HDACs induce growth arrest, differentiation or apoptosis of cancer cells in vitro and in vivo. Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Subunit: Interacts with HDAC6. Subcellular Location: Nucleus. Note=Predominantly nuclear. Tissue Specificity: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis. Similarity: Belongs to the histone deacetylase family. Database links: Entrez Gene: 79885 Human Entrez Gene: 232232 Mouse Entrez Gene: 297453 Rat Omim: 607226 Human SwissProt: Q96DB2 Human SwissProt: Q91WA3 Mouse Unigene: 728246 Human Unigene: 744132 Human Unigene: 206218 Mouse Unigene: 28065 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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