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Product Name Anti-phospho-Caspase 6 (Ser257)/APC Chinese Name APC标记的磷酸化半胱胺酸蛋白酶蛋白6抗体 Alias Apoptosis-related cysteine protein; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Human cysteine protease Mch2 isoform alpha; Mch 2; Mch2; CASP6_HUMAN. Product Type Phosphorylated anti Research Area Cell biology immunology Neurobiology Signal transduction Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 11/33kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated Synthesised phosphopeptide derived from human Caspase 6 around the phosphorylation site of Ser257 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Caspase-6 is involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Subunit is compose of heterodimer of a18 kDa (p18) and a 11 kDa (p11) subunit. Subcellular location at cytoplasmic. Cleavages by CPP32, caspase-8 or -10 generate the two active subunits. It belongs to the peptidase C14 family.
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
Similarity:
Belongs to the peptidase C14A family.
Database links:Entrez Gene: 839 Human
Entrez Gene: 12368 Mouse
Omim: 601532 Human
SwissProt: P55212 Human
SwissProt: O08738 Mouse
Unigene: 654616 Human
Unigene: 281379 Mouse
Unigene: 88160 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Caspase-6 与Caspase-3有38%的同源性,属胱氨酸-天冬氨酸蛋白酶家族。在凋亡执行阶段起中心作用,可被Caspase-7、-8、-10剪切。它是唯一一个可以剪切核纤层蛋白的Caspase.
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