TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Anti-Angiomotin/APC Chinese Name APC标记的血管动蛋白抗体 Alias AMOT; AMOT_HUMAN; Angiomotin; Angiomotin p130 isoform; KIAA1071. Research Area Tumour Cardiovascular immunology Signal transduction Binding protein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 118kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Angiomotin (545-620aa) Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Angiomotin is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.
Function:
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Subunit:
Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin.
Subcellular Location:
Cell junction, tight junction.
Tissue Specificity:
Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the angiomotin family.
Database links:Entrez Gene: 465814 Chimpanzee
Entrez Gene: 100054069 Horse
Entrez Gene: 154796 Human
Entrez Gene: 27494 Mouse
Entrez Gene: 707701 Rhesus monkey
Omim: 300410 Human
SwissProt: Q4VCS5 Human
SwissProt: Q8VHG2 Mouse
Unigene: 528051 Human
Unigene: 100068 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Scan Wechat Qrcode