Product Name	Anti-Collagen IV/APC
Chinese Name	APC标记的IV型Collagen protein/4型Collagen protein/Collagen protein4抗体
Alias	Arresten; Canstatin; COL4A1; HANAC; ICH; POREN1; Collagen Alpha 1(IV) Chain; Collagen IV Alpha 1 Polypeptide; Collagen Of Basement Membrane Alpha 1 Chain; Collagen Of Basement Membrane Alpha 2 Chain; Collagen Type IV Alpha 1; DKFZp686I14213; FLJ22259; collagen alpha-1(IV) chain preproprotein; collagen alpha-1(IV) chain preproprotein; Col4a1 protein; collagen of basement membrane, alpha-1 chain; collagen IV, alpha-1 polypeptide; collagen alpha-1(IV) chain; COL4A1 NC1 domain; CO4A1_HUMAN.
Research Area	Tumour  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	165kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Collagen alpha-1(IV) chain
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Collagen IV is a major constituent of the basement membranes along with laminins, proteoglycans and enactins. It is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. It can form insoluble fibers with high tensile strength. Collagen IV is useful in detecting the loss of parts of basement membranes in carcinomas. Function: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. Subunit: There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane. Tissue Specificity: Highly expressed in placenta. Post-translational modifications: Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. Proteolytic processing produces the C-terminal NC1 peptide, arresten. DISEASE: Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage (BSVDH) [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant. Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy aneurysms and muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria and bilateral large cysts. Histologic analysis revealed complex basement membrane defects in kidney and skin. The systemic angiopathy appears to affect both small vessels and large arteries. Defects in COL4A1 are a cause of familial porencephaly (POREN1) [MIM:175780]. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect or arrest in the development of the cerebral ventricles. Similarity: Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. Database links: Entrez Gene: 282191 Cow Entrez Gene: 317711 Cow Entrez Gene: 407107 Cow Entrez Gene: 508632 Cow Entrez Gene: 511602 Cow Entrez Gene: 1282 Human Entrez Gene: 1284 Human Entrez Gene: 1285 Human Entrez Gene: 1286 Human Entrez Gene: 1287 Human Entrez Gene: 12826 Mouse Entrez Gene: 12827 Mouse Entrez Gene: 12828 Mouse Entrez Gene: 12829 Mouse Entrez Gene: 12830 Mouse Entrez Gene: 397502 Pig Entrez Gene: 290905 Rat Entrez Gene: 301562 Rat Entrez Gene: 306628 Rat Entrez Gene: 363265 Rat Entrez Gene: 363457 Rat Omim: 120070 Human Omim: 120090 Human Omim: 120130 Human Omim: 120131 Human Omim: 303630 Human SwissProt: P02462 Human SwissProt: P08572 Human SwissProt: P29400 Human SwissProt: P53420 Human SwissProt: Q01955 Human SwissProt: P02463 Mouse SwissProt: P08122 Mouse SwissProt: Q9QZR9 Mouse SwissProt: Q9QZS0 Mouse Unigene: 17441 Human Unigene: 369089 Human Unigene: 570065 Human Unigene: 591645 Human Unigene: 738 Mouse Unigene: 121139 Rat Unigene: 22075 Rat Unigene: 53801 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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