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Product Name Anti-RAB11FIP1/AF647 Chinese Name AF647标记的G蛋白Binding proteinRAB相互作用蛋白抗体 Alias FLJ22524; FLJ22622; HGNC:30265; MGC78448; No Rab11 binding protein 1A; NOEL1A; Rab coupling protein; Rab effector protein; Rab interacting recycling protein; Rab-coupling protein; RAB11 family interacting protein 1 (class I); Rab11 family interacting protein 1D; Rab11 family-interacting protein 1; Rab11 FIP1; Rab11-FIP1; RAB11FIP1; RCP; RFIP1_HUMAN. Research Area Cell biology Signal transduction G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 137kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RAB11FIP1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
Function:
A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.
Subcellular Location:
Recycling endosome. Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC) and Cytoplasmic vesicle, phagosome membrane. Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).
Tissue Specificity:
Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.
Similarity:
Contains 1 C2 domain.
Contains 1 FIP-RBD domain.
Database links:Entrez Gene: 80223 Human
Entrez Gene: 75767 Mouse
Omim: 608737 Human
SwissProt: Q6WKZ4 Human
SwissProt: Q9D620 Mouse
Unigene: 191179 Human
Unigene: 205335 Mouse
Unigene: 49288 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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