Product Name	Anti-PPIP5K2/HISPPD1/AF647
Chinese Name	AF647标记的组氨酸酸性磷酸酶结构域蛋白1抗体
Alias	Diphosphoinositol pentakisphosphate kinase 2; HISPPD1; Histidine acid phosphatase domain containing 1; Histidine acid phosphatase domain containing protein 1; Histidine acid phosphatase domain-containing protein 1; hsVIP2; Inositol heptaphosphate kinase 2; Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; InsP6 and PP IP5 kinase 2; InsP6 and PP-IP5 kinase 2; IP7K2; PP IP5 kinase 2; Ppip5k2; VIP1 homolog 2; VIP2; VIP2_HUMAN.
Research Area	Tumour  Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	138kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PPIP5K2/HISPPD1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).[supplied by OMIM, Mar 2008] Function: Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP-InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2-InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Subcellular Location: Cytoplasm > cytosol. Tissue Specificity: Belongs to the histidine acid phosphatase family. VIP1 subfamily. Similarity: Belongs to the histidine acid phosphatase family. VIP1 subfamily. Database links: Entrez Gene: 101091503 Cat Entrez Gene: 780855 Cow Entrez Gene: 488883 Dog Entrez Gene: 100712709 Guinea pig Entrez Gene: 100064726 Horse Entrez Gene: 23262 Human Entrez Gene: 227399 Mouse Entrez Gene: 501194 Rat Omim: 611648 Human SwissProt: O43314 Human SwissProt: Q6ZQB6 Mouse Unigene: 212046 Human Unigene: 220817 Mouse Unigene: 417682 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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