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Rabbit Anti-PTDSS1/AF647 Conjugated antibody
Rabbit Anti-PTDSS1/AF647 Conjugated antibody
Phosphatidylserine synthase 1; PSS1; PSSA; PTSS1_HUMAN; PtdSer synthase 1; Serine exchange enzyme I.
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  • NO.:SL19583R-AF647
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,(predicted: Human,Rat,Pig,Cow,Horse,Sheep,)
    Applications:ICC IF
    concentration:1mg/ml
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Details

Product Name Anti-PTDSS1/AF647
Chinese Name AF647标记的磷脂合成酶1抗体
Alias Phosphatidylserine synthase 1; PSS1; PSSA; PTSS1_HUMAN; PtdSer synthase 1; Serine exchange enzyme I.  
Research Area Tumour  Cell biology  Signal transduction  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Sheep, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 55kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human PTDSS1
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Function:
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.

Subcellular Location:
Membrane; Multi pass membrane protein.

DISEASE:
The disease is caused by mutations affecting the gene represented in this entry.
Disease description:A syndrome of intellectual disability and multiple congenital anomalies that features generalized craniotubular hyperostosis. LMHD is characterized by the combination of sclerosing bone dysplasia, intellectual disability and distinct craniofacial, dental, cutaneous and distal limb anomalies. The progressive generalized hyperostosis associated with this syndrome affects the cranium, the vertebrae and the diaphyses of tubular bones, leading to severe growth restriction

Similarity:
Belongs to the phosphatidyl serine synthase family.

Database links:

Entrez Gene: 9791 Human

Entrez Gene: 19210 Mouse

Entrez Gene: 314553 Rat

Omim: 612792 Human

SwissProt: P48651 Human

SwissProt: Q99LH2 Mouse

Unigene: 292579 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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