Product Name	Anti-HMW Cytokeratin/AF647
Chinese Name	AF647标记的高分子量细胞角蛋白抗体
Alias	CK 13; CK 14; CK 15; CK 16; CK13; CK14; CK15; CK16; Cytokeratin 13; Cytokeratin 14; Cytokeratin 15; Cytokeratin 16; EBS3; EBS4; K13; K14; K15; K16; K1CO; K1CP; Keratin 13; Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); Keratin 14; Keratin 15; Keratin 15, basic; Keratin 15, beta; Keratin 16 (focal non epidermolytic palmoplantar keratoderma); Keratin 16; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 16; KRT13; KRT14; KRT15; KRT16; KRT16A; KRTB; NEPPK; NFJ; Type I cytoskeletal 15.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Horse, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	51kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HMW Cytokeratin
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008] Function: Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1 (67), CK2 (65.5), CK3 (64), CK4 (59), CK5 (58), CK6 (56), CK7 (54), CK8 (52.5) and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10 (56.5), CK12 (56), CK13 (53), CK14 (50), CK16( 48), CK17 (46), CK18 (45), CK19(48) and CK20(46). Subunit: Heterotetramer of two type I and two type II keratins.disulfide-linked keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins. Subcellular Location: Cytoplasmic Similarity: Belongs to the intermediate filament family. Database links: Entrez Gene: 408039 Chicken Entrez Gene: 408040 Chicken Entrez Gene: 507464 Cow Entrez Gene: 3860 Human Entrez Gene: 3861 Human Entrez Gene: 3866 Human Entrez Gene: 3868 Human Entrez Gene: 16663 Mouse Entrez Gene: 16664 Mouse Entrez Gene: 16665 Mouse Entrez Gene: 16666 Mouse Entrez Gene: 287699 Rat Entrez Gene: 287700 Rat Entrez Gene: 287701 Rat Entrez Gene: 303530 Rat Omim: 148030 Human Omim: 148065 Human Omim: 148066 Human Omim: 148067 Human SwissProt: Q6PVZ1 Chicken SwissProt: Q17QL7 Cow SwissProt: P02533 Human SwissProt: P08779 Human SwissProt: P13646 Human SwissProt: P19012 Human SwissProt: P08730 Mouse SwissProt: Q61414 Mouse SwissProt: Q61781 Mouse SwissProt: Q9Z2K1 Mouse SwissProt: Q6IFV1 Rat SwissProt: Q6IFV3 Rat SwissProt: Q6IFV4 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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