Product Name	Anti-DOC2A/AF647
Chinese Name	AF647标记的DOC2A蛋白抗体
Alias	Doc2; Doc2-alpha; Doc2a; DOC2A_HUMAN; Double C2 like domains, alpha; Double C2-like domain-containing protein alpha.
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	44kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DOC2A
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Function: Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. Subcellular Location: Lysosome. Cytoplasmic vesicle; secretory vesicle; synaptic vesicle membrane. Cell junction; synapse; synaptosome. Colocalizes to synaptic vesicles. Tissue Specificity: Predominantly expressed in brain. Also expressed in testis. Similarity: Contains 2 C2 domains. Database links: Entrez Gene: 8448 Human Entrez Gene: 13446 Mouse Entrez Gene: 65031 Rat Omim: 604567 Human SwissProt: Q14183 Human SwissProt: Q7TNF0 Mouse SwissProt: P70611 Rat Unigene: 355281 Human Unigene: 220257 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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