Product Name	Anti-Glypican 6/AF647
Chinese Name	AF647标记的磷脂酰基醇蛋白聚糖-6抗体
Alias	GPC 6; Glypican6; Glypican-6; Glypican 6 [Precursor]; Glypican proteoglycan 6; GPC 6; GPC6; MGC126288; Secreted glypican 6.
Research Area	Cell biology  immunology  Signal transduction  Growth factors and hormones  Cell Surface Molecule  Cytoskeleton  Zinc finger protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
Applications	Flow-Cyt=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	56kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Glypican 6
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Glypican 6 is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti proteases. The glypicans comprise a family of glycosylphosphatidylinositol anchored heparan sulfate proteoglycans. The glypicans have been implicated in the control of cell growth and division. Function: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted glypican-6: Secreted, extracellular space. Tissue Specificity: Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. DISEASE: Defects in GPC6 are a cause of omodysplasia type 1 (OMOD1) [MIM:258315]. OMOD1 is a rare autosomal recessive skeletal dysplasia characterized by severe congenital micromelia with shortening and distal tapering of the humeri and femora to give a club-like appearance. Typical facial features include a prominent forehead, frontal bossing, short nose with a depressed broad bridge, short columella, anteverted nostrils, long philtrum, and small chin. Similarity: Belongs to the glypican family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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