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Product Name Anti-FEM1A/AF647 Chinese Name AF647标记的前列腺素E受体4相关蛋白抗体 Alias EPRAP; Fem-1 homolog a (C. elegans); Fem1 homolog a; FEM1-alpha-A; FEM1a-A; Fem1aa; Feminization 1 homolog a (C. elegans); Feminization 1 homolog a; Prostaglandin E receptor 4-associated protein; Protein fem-1 homolog A; Protein fem-1 homolog A-A; FEM1A_HUMAN. Research Area Cell biology Signal transduction Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 74kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FEM1A Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
FEM1A is a caspase substrate homologous to the C. Elegans sex determining protein, FEM-1. Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4. Overexpression of FEM1A in mammalian cells is reported to induce apoptosis.
Function:
Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4.
Subunit:
Component of some E3 ubiquitin-protein ligase complex. Interacts with PTGER4.
Subcellular Location:
Cytoplasm (Probable).
Tissue Specificity:
Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).
Similarity:
Belongs to the fem-1 family.
Contains 9 ANK repeats.
Contains 2 TPR repeats.
Database links:
Entrez Gene: 55527 Human
Entrez Gene: 14154 Mouse
GenBank: NP_061178.1 Human
SwissProt: Q9BSK4 Human
SwissProt: Q8C4V3 Mouse
Unigene: 515082 Human
Unigene: 290813 Mouse
Unigene: 228392 Rat
Unigene: 97265 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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