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Rabbit Anti-RCL/AF647 Conjugated antibody
Rabbit Anti-RCL/AF647 Conjugated antibody
c Myc responsive; c Myc responsive protein Rcl; C6orf108; Chromosome 6 open reading frame 108; Putative c Myc responsive; RCL_HUMAN.
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  • NO.:SL7827R-AF647
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Dog,Pig,Horse,Rabbit,)
    Applications:IF
    concentration:1mg/ml
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Details

Product Name Anti-RCL/AF647
Chinese Name AF647标记的c-Myc应答蛋白抗体
Alias c Myc responsive; c Myc responsive protein Rcl; C6orf108; Chromosome 6 open reading frame 108; Putative c Myc responsive; RCL_HUMAN.  
Research Area Cell biology  Cyclin  Cell differentiation  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, )
Applications IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 19kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human RCL/c Myc responsive
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
This gene was identified on the basis of its stimulationby c-Myc protein. The latter is a transcription factor thatparticipates in the regulation of cell proliferation,differentiation, and apoptosis. The exact function of this gene isnot known but studies in rat suggest a role in cellularproliferation and c-Myc-mediated transformation. Two alternativetranscripts encoding different proteins have been described.[provided by RefSeq, Jul 2008].

Function:
Catalyzes the cleavage of the N-glycosidic bond ofdeoxyribonucleoside 5'-monophosphates to yield deoxyribose5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside5'-monophosphates containing purine bases are preferred to thosecontaining pyrimidine bases (By similarity).

Subunit:
Monomer and homodimer (By similarity).

Subcellular Location:
Nucleus (By similarity). Cytoplasm.

Tissue Specificity:
Expressed at low levels in brain, colon, lung,peripheral blood leukocytes, placenta, small intestine, and thymus.Expressed at high levels in heart, kidney, liver, skeletal muscleand spleen. Overexpressed in a significant proportion of breastcancers.

Similarity:
Belongs to the deoxyribonucleoside 5'-monophosphateN-glycosidase family

Database links:
UniProtKB/Swiss-Prot: O43598.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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