Product Name	Anti-GAP43/AF594
Chinese Name	AF594标记的神经生长相关蛋白43单克隆抗体
Alias	Growth Associated Protein-43; Neuromodulin; Axonal membrane protein GAP 43; B-50; F1; GAP 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; GAP-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071.
Research Area	Tumour  immunology  Neurobiology
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	6F11
React Species	Mouse, Rat,  (predicted: Human, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	43kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	Recombinant human GAP43 Protein
Lsotype	IgG
Purification	affinity purified by Protein G
Storage Buffer	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Subunit: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Subcellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. Post-translational modifications: Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity. Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2. Similarity: Belongs to the neuromodulin family. Contains 1 IQ domain. Database links: Entrez Gene: 2596 Human Entrez Gene: 14432 Mouse Entrez Gene: 29423 Rat GenBank: NP_002036 Human Omim: 162060 Human SwissProt: P17677 Human SwissProt: P06837 Mouse SwissProt: P07936 Rat Unigene: 134974 Human Unigene: 1222 Mouse Unigene: 10928 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Neurobiology相关蛋白（Neurobiology）；神经Maker GAP43 （Growth associated protein-43）又称作neuromodulin，是一个轴突膜蛋白，是一种神经特异性的蛋白质，参与神经细胞外生长及突触发育形成和神经细胞再生。在神经元发育和再生过程中以高水平表达。能调解轴突延伸作用，改变细胞形态。作为细胞内信号，可大大增强与G蛋白偶联的受体转运作用。 神经生长相关蛋白-GAP-43和神经细胞黏附因子(neural cell adhesion molecule,NCAM)与突触可塑性密切相关.GAP-43是一种神经The cell membrane上的特异性磷蛋白,在神经发育和再生过程中呈现高表达,被作为突触生长的Maker,有称脊髓生长相关蛋白 GAP-43与CaM结合,参与G蛋白相互作用,神经递质的释放,作用于胞吞/胞吐过程,通过小囊溶合或诱导生长锥和突触前末端的胞吞促进膜扩展,与海马长时程增强密切相关. 神经细胞黏附因子是细胞表面glycoprotein大家族的成员之一,促进轴突生长,对长时记忆的保持有重要影响,同时,GAP-43对其具调节作用，广泛而深入地研究GAP-43意义深远。

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