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Product Name Anti-CNOT6/AF594 Chinese Name AF594标记的细胞表面Chemokine受体4相关蛋白6抗体 Alias carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4 like; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex, subunit 6; CNOT6; Cytoplasmic deadenylase. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 63kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CNOT6 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
CNOT6 is a widely expressed subunit of the CCR4-NOT transcription complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. CNOT6 belongs to the CCR4/nocturin family and contains three LRR (leucine-rich) repeats. In the cytoplasm, CNOT6 acts as a poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the Fos gene.
Function:
Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any.
Subunit:
Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Interacts with UNR. Interacts with ZNF335.
Subcellular Location:
Cytoplasmic and Nuclear.
Similarity:
Belongs to the CCR4/nocturin family.
Contains 4 LRR (leucine-rich) repeats.
Database links:
Entrez Gene: 57472 Human
Entrez Gene: 104625 Mouse
Omim: 608951 Human
SwissProt: Q9ULM6 Human
SwissProt: Q8K3P5 Mouse
Unigene: 608380 Human
Unigene: 247113 Mouse
Unigene: 431753 Mouse
Unigene: 93562 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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