Product Name	Anti-ECE1/AF594
Chinese Name	AF594标记的内皮素转化酶1抗体
Alias	ECE 1; ECE-1; Endothelin converting enzyme 1; ECE1_HUMAN.
Research Area	Tumour  immunology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Rabbit, Guinea Pig, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	85kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ECE1 C-terminus
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]. Function: Converts big endothelin-1 to endothelin-1. Subunit: Homodimer; disulfide-linked. Subcellular Location: Cell Membrane. Single pass type II membrane protein. Tissue Specificity: All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney. DISEASE: Defects in ECE1 are a cause of Hirschsprung disease cardiac defects and autonomic dysfunction (HSCRCDAD) [MIM:613870]. It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction. Similarity: Belongs to the peptidase M13 family. Database links: Entrez Gene: 281133 Cow Entrez Gene: 1889 Human Entrez Gene: 230857 Mouse Entrez Gene: 94204 Rat Omim: 600423 Human SwissProt: P42891 Cow SwissProt: P42892 Human SwissProt: Q4PZA2 Mouse SwissProt: P42893 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 内皮素转化酶(endothelin—converting enzyme-1)是内皮素ET生物合成的关键酶，在体内内皮素生物活性调节上起着极为重要的作用。

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