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Product Name Anti-Matrilin 1/AF594 Chinese Name AF594标记的软骨基质蛋白抗体 Alias Cartilage matrix protein; CMP; CRTM; Mat1; MATN1; Matrilin-1; MGC95132; Cartilage matrix protein 1. Research Area immunology Developmental biology Immunogen Species Rabbit Clonality Polyclonal React Species Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 55kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Matrilin 1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. Mutations of this gene have been associated with variety of inherited chondrodysplasias. [provided by RefSeq]
Function:
Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.
Subunit:
Homotrimer. Interacts with COMP.
Subcellular Location:
Secreted, extracellular space, extracellular matrix.
Similarity:
Contains 1 EGF-like domain.
Contains 2 VWFA domains.
Database links:Entrez Gene: 4146 Human
Entrez Gene: 17180 Mouse
Omim: 115437 Human
SwissProt: P21941 Human
SwissProt: P51942 Mouse
Unigene: 150366 Human
Unigene: 271796 Mouse
Unigene: 15159 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Matrilins 是一组非胶原的Extracellular matrix蛋白家族,该蛋白家族分别为 Matrilin-1, Matrilin-2, Matrilin-3 和 Matrilin-4 。
Matrilnin-1 和 Matrilin-3 主要分布在生长的软骨组织中,Matrilin-2 和 Matrilin-4 分布较广,主要分布于软骨的增殖和肥大区,在软骨膜、骨膜及骨组织中,而且,它也分布在许多非骨组织中,如腱、韧带、真皮、心脏、平滑肌、消化道和呼吸道等。
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