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Product Name Anti-TNFSF4/AF594 Chinese Name AF594标记的Tumour坏死因子配体超家族成员4抗体 Alias CD 134L; CD 252; CD134; CD134 ligand; CD134L; CD252; CD252 antigen; glycoprotein 34 kd; Glycoprotein Gp34; GP34; OX-40L; OX40 antigen ligand; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFL4_RAT; Tnfsf4; Tumor necrosis factor (ligand) superfamily member 4; Tumor necrosis factor ligand superfamily member 4; TXGP1. Research Area Cell biology immunology Cell Surface Molecule lymphocyte t-lymphocyte cell factor Immunogen Species Rabbit Clonality Polyclonal React Species Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 22kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from rat TNFSF4 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq]
Function:
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Subunit:
Homotrimer (Probable).
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Tissue Specificity:
Detected in T-cell lines, but not in a macrophage cell line.
Similarity:
Belongs to the tumor necrosis factor family.
Database links:Entrez Gene: 7292 Human
Entrez Gene: 22164 Mouse
Omim: 603594 Human
SwissProt: P23510 Human
SwissProt: P43488 Mouse
Unigene: 181097 Human
Unigene: 4994 Mouse
Unigene: 30043 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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