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Product Name Anti-EIF2AK4/GCN2/AF594 Chinese Name AF594标记的蛋白激酶GCN2蛋白抗体 Alias EIF2AK4; Eukaryotic Translation Initiation Factor 2-alpha kinase 4; GCN2-like protein; KIAA1338; E2AK4_HUMAN; Eif2ak4; Eukaryotic Translation Initiation Factor 2 alpha kinase 4; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; MGCN2. Research Area Neurobiology Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Dog, Horse, Rabbit, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 189kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GCN2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
GCN2 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 to downregulate protein synthesis in response to varied cellular stresses.
Function:
Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.
Tissue Specificity:
Widely expressed.
Post-translational modifications:
Autophosphorylated on threonine residues.
Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Contains 2 protein kinase domains.
Contains 1 RWD domain.
Database links:Entrez Gene: 440275 Human
Entrez Gene: 27103 Mouse
Omim: 609280 Human
SwissProt: Q9P2K8 Human
SwissProt: Q9QZ05 Mouse
Unigene: 656673 Human
Unigene: 217616 Mouse
Unigene: 8333 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GCN2蛋白的作用;可能是将短期记忆变成长期记忆的一个主控调节因子,GCN2蛋白在长期记忆形成中功能的发现将可能帮助研究人员开发出提高记忆力丧失病人的记忆力的药物。
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