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Product Name Anti-FUT8/AF594 Chinese Name AF594标记的岩藻糖转移酶8抗体 Alias Alpha (1,6) fucosyltransferase; Alpha-(1; Alpha1 6FucT; alpha1-6FucT; Fucosyltransferase 8 (alpha (1,6) fucosyltransferase); Fucosyltransferase 8; FUT8; FUT8_HUMAN; GDP fucose glycoprotein fucosyltransferase; GDP L Fuc:N acetyl beta D glucosaminide alpha1,6 fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1; Glycoprotein 6 alpha L fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; 6)-fucosyltransferase; 6-fucosyltransferase. Research Area Tumour Cell biology immunology Signal transduction TumourCell biologyMaker Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Pig, Cow, Horse, Rabbit, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 66kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FUT8 corresponding to amino acids 321-368. Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. There are 2 isoforms produced by alternative splicing. Immunogen is not present in isoform 2 (also known as Retinal).
Function:
Catalyzes the addition of fucose in alpha 1-6 linkage tocthe first GlcNAc residue, next to the peptide chains in N-glycans.
Subcellular Location:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Similarity:
Belongs to the glycosyltransferase 23 family.
Contains 1 SH3 domain.
Database links:Entrez Gene: 2530 Human
Entrez Gene: 53618 Mouse
Omim: 602589 Human
SwissProt: Q9BYC5 Human
SwissProt: Q9WTS2 Mouse
Unigene: 654961 Human
Unigene: 35628 Mouse
Unigene: 1717 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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