Product Name	Anti-ST18/AF594
Chinese Name	AF594标记的Tumour抑制蛋白18抗体
Alias	KIAA0535; St18; ST18_HUMAN; suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein); Suppression of tumorigenicity 18 protein; Suppression of tumorigenicity protein 18; Zinc finger protein 387; Znf387.
Research Area	Tumour  Cell biology  Stem cells  Zinc finger protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	115kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ST18/Znf387
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: ST18 is a 1,047 amino acid nuclear protein that is expressed at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Containing six C2HC-type zinc fingers and an SMC domain, ST18 is a repressor protein that binds to DNA sequences containing a specific bipartite element. ST18 is considered a transcription factor that represses basal transcription activity from target promoters and Inhibits colony formation in cultured breast cancer cells. ST18 is encoded by a gene located on human chromosome 8, which consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. Function: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells. Subcellular Location: Nucleus. Tissue Specificity: Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells. Similarity: Contains 6 C2HC-type zinc fingers. Database links: Entrez Gene: 9705 Human Entrez Gene: 240690 Mouse Entrez Gene: 266680 Rat SwissProt: O60284 Human SwissProt: Q80TY4 Mouse SwissProt: Q9QX27 Rat Unigene: 655499 Human Unigene: 234612 Mouse Unigene: 91311 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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