Product Name	Anti-GBA2/AF594
Chinese Name	AF594标记的β葡萄糖苷酶2抗体
Alias	AD035; Beta glucocerebrosidase 2; Beta glucosidase 2; DKFZp762K054; glucosidase, beta (bile acid) 2; Glucosylceramidase 2; KIAA1605; MGC16895; Non lysosomal glucosylceramidase; GBA2_HUMAN.
Research Area	Tumour  Cell biology  Developmental biology  Signal transduction  The new supersedes the old  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	105kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GBA2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Beta-glucosidase 2, also known as non-lysosomal glucosylceramidase (NLGase), Glucosylceramidase 2, GBA2 or AD035, is a 927 amino acid non-lysosomal glucosylceramidase that catalyzes glucosylceramide into ceramide and free glucose, and is suggested to play a role in carbohydrate transport and metabolism. A single-pass membrane protein, Beta-glucosidase 2 exists as three alternatively spliced isoforms that are widely expressed but found at highest levels in placenta, kidney, brain, skeletal muscle, kidney and heart, with low levels found in liver. Beta-glucosidase 2 activity has been linked to sphingomyelin generation and prevention of glycolipid accumulation. The gene encoding Beta-glucosidase 2 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Function: GBA2 is a non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. It is involved in sphingomyelin generation and prevention of glycolipid accumulation. GBA2 may also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Subcellular Location: Cell membrane; Single-pass membrane protein. Note=Not localized to lipid rafts. Tissue Specificity: Widely expressed. Highly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower level in liver. Similarity: Belongs to the non-lysosomal glucosylceramidase family. Database links: Entrez Gene: 57704 Human Entrez Gene: 230101 Mouse GenBank: NM_020944.2 Human Omim: 609471 Human SwissProt: Q9HCG7 Human SwissProt: Q69ZF3 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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