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Product Name Anti-KLRA3/Ly49C/AF594 Chinese Name AF594标记的Natural killer cells凝集素样受体3抗体 Alias 5E6; Killer cell lectin like receptor 3; Killer cell lectin like receptor subfamily A member 3; KLRA 3; Ly 49c; KLRA3_MOUSE; Ly49C; Lymphocyte antigen 49c; MGC123910; Natural killer cell associated antigen 2; Nk 2; NK 2.1; Nk2; Nk2.1; OTTMUSP00000026267; T cell surface glycoprotein Ly 49C. Research Area Cell biology immunology The cell membrane受体 Natural killer cells Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 31kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse KLRA3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
KLRA3 (also known as Ly49C) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA3 is thought to be an inhibitory receptor, recognizing peptide–receptive H-2Kb.
Function:
Receptor on natural killer (NK) cells for class I MHC.
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Similarity:
Contains 1 C-type lectin domain.
Database links:Entrez Gene: 16634 Mouse
SwissProt: Q64329 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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