Product Name	Anti-TRIM68/AF594
Chinese Name	AF594标记的TRIM68蛋白抗体
Alias	E3 ubiquitin-protein ligase TRIM68; FLJ10369; GC109; MGC126176; RING finger protein 137; RNF 137; RNF137; Ro/SSA1 related protein; SS 56; SS-56; SS56; SSA protein SS 56; SSA protein SS-56; TRI68_HUMAN; TRIM 68; Trim68; Tripartite motif containing 68; Tripartite motif containing protein 68; Tripartite motif-containing protein 68.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Pig, Cow, Horse, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	56kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TRIM68
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes a protein which contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells. [provided by RefSeq, Oct 2011] Function: Functions as an ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. Subunit: Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60. Subcellular Location: Cytoplasm > perinuclear region. Nucleus. Colocalized with AR in nucleus. Tissue Specificity: Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells. Post-translational modifications: Auto-ubiquitinated. Similarity: Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger. Database links: Entrez Gene: 55128 Human Entrez Gene: 101700 Mouse Omim: 613184 Human SwissProt: Q6AZZ1 Human SwissProt: Q8K243 Mouse Unigene: 523438 Human Unigene: 738828 Human Unigene: 39043 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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