Product Name	Anti-Nkx2.6/AF555
Chinese Name	AF555标记的转录因子同源蛋白Nkx2.6抗体
Alias	CSX2; Homeobox protein NK-2 homolog F; homeobox protein NK2 homolog F; Homeobox protein Nkx-2.6; Homeobox protein Nkx2.6; NK2 homeobox 6; NK2 transcription factor related, locus 6 (Drosophila); NKX2-6; NKX26_MOUSE; NKX2F; NKX4 2; Tinman paralog.
Research Area	Cardiovascular  Cell biology  Developmental biology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	32kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Nkx2.6
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011] Function: In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. Subcellular Location: Nucleus DISEASE: A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Similarity: Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 137814 Human Entrez Gene: 18092 Mouse Omim: 611770 Human SwissProt: A6NCS4 Human SwissProt: P43688 Mouse Unigene: 532654 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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