Product Name	Anti-NOXO1/AF555
Chinese Name	AF555标记的NADPH氧化酶调节蛋白1抗体
Alias	NADPH oxidase organizer 1; NADPH oxidase regulatory protein; Nox organizer 1; Nox organizing protein 1; Nox-organizing protein 1; NOXO1; NOXO1_HUMAN; P41NOX; Regulatory protein P41NOX; SH3 and PX domain-containing protein 5; SH3PXD5.
Research Area	Tumour  Cell biology  Signal transduction  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	41kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NOXO1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012] Function: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. Subcellular Location: Cell membrane. Isoform 3 associates with the plasma membrane in a lipid-dependent manner.Target information above from: UniProt accession Q8NFA2 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res. 38:D142-D148 (2010) . Tissue Specificity: Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. Similarity: Contains 1 PX (phox homology) domain. Contains 2 SH3 domains. Database links: Entrez Gene: 124056 Human Entrez Gene: 71893 Mouse Entrez Gene: 302976 Rat Omim: 611256 Human SwissProt: Q8NFA2 Human SwissProt: Q8VCM2 Mouse Unigene: 191762 Human Unigene: 390971 Mouse Unigene: 137764 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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