Product Name	Anti-MICALCL/AF555
Chinese Name	AF555标记的ERK2结合睾丸蛋白1抗体
Alias	Ebitein-1; EBITEIN1; ERK2-binding testicular protein 1; FLJ14966; MICAL C-terminal-like protein; Micalcl; MICLK_HUMAN; OTTHUMP00000230951.
Research Area	Cell biology  Signal transduction  Apoptosis  Cyclin  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Pig, Cow, Horse, Rabbit, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	77kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MICALCL
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: MICALCL is a 695 amino acid cytoplasmic protein that belongs to the ebitein family and interacts with ERK2 during spermatozoa development. MICALCL contains a polymorphic poly-proline region and is encoded by a gene that maps to human chromosome 11p15.3. Chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. Function: May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. Subcellular Location: Cytoplasm. Similarity: Belongs to the ebitein family. Database links: Entrez Gene: 84953 Human Omim: 612355 Human SwissProt: Q6ZW33 Human Unigene: 128196 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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