Product Name	Anti-PPP2R2A/AF555
Chinese Name	AF555标记的蛋白磷酸酶2A-B55α抗体
Alias	2ABA_HUMAN; Alpha isoform of regulatory subunit B55 protein phosphatase 2; B55A; B55ALPHA; calcineurin; PP2A subunit B B alpha isoform; PP2A subunit B B55 alpha isoform; PP2A subunit B isoform alpha; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B PR55 alpha isoform; PP2A subunit B R2 alpha isoform; PPP2R2A; PR52A; PR55A; Protein phosphatase 2 (formerly 2A) regulatory subunit B (PR 52) alpha isoform; Protein phosphatase 2 regulatory subunit B alpha; Protein phosphatase 2 regulatory subunit B alpha isoform; Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform.
Research Area	Tumour  Cell biology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	52kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PPP2R2A
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD By similarity. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Tissue Specificity: Expressed in all tissues examined. Similarity: Belongs to the phosphatase 2A regulatory subunit B family. Contains 7 WD repeats. Database links: Entrez Gene: 5520 Human Entrez Gene: 71978 Mouse Entrez Gene: 117104 Rat Omim: 604941 Human SwissProt: P63151 Human SwissProt: Q6P1F6 Mouse SwissProt: P63150 Rabbit SwissProt: P36876 Rat Unigene: 146339 Human Unigene: 273997 Mouse Unigene: 81155 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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