Product Name	Anti-MCT14/AF555
Chinese Name	AF555标记的单羧酸转运14抗体
Alias	Monocarboxylate transporter 14; FLJ30794; MCT 14; MCT14; Monocarboxylate transporter 14; MOT14_HUMAN; OTTHUMP00000204389; OTTHUMP00000204390; Slc16a14; Solute carrier family 16 (monocarboxylic acid transporters), member 14; Solute carrier family 16 member 14; Solute carrier family 16, member 14 (monocarboxylic acid transporter 14).
Research Area	Cell biology  Signal transduction  The new supersedes the old  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	56kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MCT14
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and, thus, to a cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. MCT14 (monocarboxylate transporter 14), also known as SLC16A14 (solute carrier family 16, member 14), is a 510 amino acid multi-pass membrane protein that belongs to the MCT family and functions as a proton-linked monocarboxylate transporter, effectively catalyzing the rapid transport of monocarboxylates across the membrane. Multiple isoforms of MCT14 exist due to alternative splicing events. Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates. Subcellular Location: Cell membrane. Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Database links: Entrez Gene: 151473 Human Entrez Gene: 71781 Mouse SwissProt: Q7RTX9 Human SwissProt: Q8K1C7 Mouse Unigene: 504317 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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