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Product Name Anti-p21-ARC/AF350 Chinese Name AF350标记的肌动蛋白相关蛋白2/3复合物亚基3抗体 Alias Actin related protein 2/3 complex subunit 3; ARC21; ARPC3_HUMAN; ARP2/3 complex 21 kDa subunit; ARP2/3 protein complex subunit p21; ARPC3. Research Area Cell biology Signal transduction Cytoskeleton Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Cow, Rabbit, Xenopus laevis) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 20kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human p21-ARC Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Function:
p21-ARC is part of a complex implicated in the control of actin polymerization in cells. It belongs to a complex composed of ARP2, ARP3, ARPC1, ARPC2, ARPC3, ARPC4 and ARPC5, collectively known as the ARPC3 family. p21-ARC is implicated as an important regulator of growth cone translocation, especially in the CNS (Strasser et al, 2004).
Subunit:
Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and
Subcellular Location:
Cytoplasm, cytoskeleton. Cell projection.
Similarity:
Belongs to the ARPC3 family.
Database links:Entrez Gene: 10094 Human
Entrez Gene: 56378 Mouse
Entrez Gene: 415204 Zebrafish
Omim: 604225 Human
SwissProt: O15145 Human
SwissProt: Q9JM76 Mouse
Unigene: 524741 Human
Unigene: 275942 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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