Product Name	Anti-TOP3B/AF350
Chinese Name	AF350标记的DNA拓扑异构酶3-β1抗体
Alias	DNA topoisomerase 3 beta 1; DNA topoisomerase 3-beta-1; DNA topoisomerase III beta 1; DNA topoisomerase III beta-1; FLJ39376; TOP 3B; TOP3B; TOP3B_HUMAN; TOP3B1; Topo III beta; Topoisomerase (DNA) III beta; Topoisomerase DNA III beta; Topoisomerase III beta; Topo IIIβ-1; Topo IIIβ 1; Topo-IIIβ1.
Research Area	Tumour  Cell biology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	97kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TOP3B
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013] Function: Possesses negatively supercoiled DNA relaxing activity. Tissue Specificity: Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas. Similarity: Belongs to the prokaryotic type I/III topoisomerase family. Contains 1 Toprim domain. Database links: Entrez Gene: 8940 Human Entrez Gene: 21976 Mouse Omim: 603582 Human SwissProt: O95985 Human SwissProt: Q9Z321 Mouse Unigene: 436401 Human Unigene: 326089 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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