Product Name	Anti-HDGFRP3/AF350
Chinese Name	AF350标记的肝癌衍生生长因子相关蛋白3抗体
Alias	CGI 142; HDGF 2; HDGF-2; HDGF2; HDGFRP 3; Hdgfrp3; HDGR3_HUMAN; Hepatoma derived growth factor 2; Hepatoma derived growth factor related protein 3; Hepatoma-derived growth factor 2; Hepatoma-derived growth factor-related protein 3; HRP 3; HRP-3; HRP3.
Research Area	Tumour  Neurobiology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	23kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HDGFRP3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Hepatoma derived growth factor (HDGF) is the original member of a family of polypeptides designated HDGF-related proteins (HRPs). HDGF was initially characterized as a secreted mitogen from the Huh-7 human hepatoma cell line. This nuclear targeted vascular smooth muscle cell mitogen (VSM) is a heparin-binding protein that is highly expressed in tumor cells, where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. During development, HDGF expression is high in the nucleus and cytoplasm of smooth muscle and endothelial cells. The HRP family contains four proteins, HRP-1, HRP-2, HRP-3 and HRP-4. HRP-1 and HRP-4 are expressed only in testis, while HRP-2 is widely expressed in different tissues. HRP-3 can be found solely in the nervous system. Specifically it is strongly expressed in bulbus, olfactorius, piriform cotrex and amygdala complex, while HRP-2 in brain is located in the the thalamus, prefrontal and parietal cortex, neurohypophysis and cerebellum. In the central nervous system, HRPs play a role in neuron proliferation and cell survival. Function: Enhances DNA synthesis and may play a role in cell proliferation. Subcellular Location: Nucleus. Tissue Specificity: Detected in testis, heart, spinal cord and brain. Similarity: Belongs to the HDGF family. Contains 1 PWWP domain. Database links: Entrez Gene: 50810 Human Entrez Gene: 29877 Mouse Entrez Gene: 252941 Rat SwissProt: Q9Y3E1 Human SwissProt: Q9JMG7 Mouse SwissProt: Q923W4 Rat Unigene: 513954 Human Unigene: 392934 Mouse Unigene: 17383 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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