Product Name	Anti-ESF1/AF350
Chinese Name	AF350标记的ESF1蛋白抗体
Alias	ABT1-associated protein; ABTAP; bA526K24.1; C20orf6; Esf1; ESF1 homolog; ESF1_HUMAN; FLJ20368; HDCMC28P; OTTHUMP00000030301.
Research Area	Cell biology  Transporter  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	99kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ESF1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that are required for transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH and sequence-specific factors that regulate gene expression. The basal transcription factors and Pol II form a specific multi-protein complex near the transcription start site by interacting with core promotor elements such as the TATA box, generally located 25-30 base pairs upstream of the transcription start site. ABT1 (activator of basal transcription 1) is a nuclear protein that associates with the TATA-binding protein (TBP) and enhances basal transcription activity of class II promoters. ABT1 forms a complex with ESF1, also designated ABT1-associated protein (ABTAP), which disrupts ABT1 interaction with TBP and suppresses ABT1-induced activation of Pol II-directed transcription. The ABT1/ESF1 complex colocalizes in the nucleolus and nucleoplasm. Function: May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1. Subcellular Location: Nucleus； nucleolus. Nucleus； nucleoplasm. Similarity: Belongs to the ESF1 family. Database links: Entrez Gene: 51575 Human SwissProt: Q9H501 Human Unigene: 369284 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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