Product Name	Anti-phospho-EIF4B (Ser406)/AF350
Chinese Name	AF350标记的磷酸化真核翻译起始因子4B抗体
Alias	eIF4B (phospho S406); p-eIF4B (phospho S406); EIF 4B; EIF-4B; Eukaryotic initiation factor 4B; IF4B_HUMAN.
Product Type	Phosphorylated anti
Research Area	Transporter  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Cow, Horse, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	69kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human EIF4B around the phosphorylation site of Ser406
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: eIF4B is required for the binding of mRNA to ribosomes. It functions in close association with eIF4F and eIF4A. It binds near the 5'-terminal cap of mRNA in the presence of eIF4F and ATP. It promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both eIF4A and eIF4F (referenced from swissprot). Function: Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. Post-translational modifications: Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex. Similarity: Contains 1 RRM (RNA recognition motif) domain. Database links: Entrez Gene: 1975 Human Entrez Gene: 75705 Mouse Entrez Gene: 300253 Rat Omim: 603928 Human SwissProt: P23588 Human SwissProt: Q8BGD9 Mouse Unigene: 648394 Human Unigene: 702041 Human Unigene: 290022 Mouse Unigene: 391795 Mouse Unigene: 95954 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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