Product Name	Anti-DCUN1D3/AF350
Chinese Name	AF350标记的DCN1样蛋白3抗体
Alias	44M2.4; DCN1 defective in cullin neddylation 1 domain containing 3 (S. cerevisiae); DCN1 defective in cullin neddylation 1 domain containing 3; DCN1 like protein 3; DCN1-like protein 3; DCNL3_HUMAN; DCUN1 domain containing protein 3; DCUN1 domain-containing protein 3; dcun1d3; Defective in cullin neddylation protein 1 like protein 3; Defective in cullin neddylation protein 1-like protein 3; DKFZp686O0290; FLJ41725; MGC48972.
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	34kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DCUN1D3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Dcun1D3 is a 304 amino acid protein that contains one Dcun1 domain. The Dcun1 domain is an approximately 190 residue module that is thought to have the features of a basic helix-loop-helix leucine zipper domain, a domain commonly found in transcription factors. It has been suggested that Dcun1D3 may be involved in cell cycle progression and cell growth. The gene that encodes Dcun1D3 maps to human chromosome 16, which encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. Chromosome 16 houses the CREBBP gene that encodes a critical CREB binding protein that is responsible for the Rubinstein-Taybi syndrome, a rare disorder characterized by mental retardation and predisposition to tumor growth and white blood cell neoplasias. Subcellular Location: Contains 1 DCUN1 domain. Database links: Entrez Gene: 123879 Human Entrez Gene: 504926 Cow Entrez Gene: 233805 Mouse Entrez Gene: 309035 Rat SwissProt: Q5E9V1 Cow SwissProt: Q8IWE4 Human SwissProt: Q8K0V2 Mouse SwissProt: Q4V8B2 Rat Unigene: 101007 Human Unigene: 31539 Mouse Unigene: 211721 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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