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Product Name Anti-IQGAP2/AF350 Chinese Name AF350标记的支架蛋白IQGAP2抗体 Alias IQGA2_HUMAN; Iqgap2; Ras GTPase activating-like protein; Ras GTPase-activating-like protein IQGAP2. Research Area Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 180kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human IQGAP2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008]
Function:
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
Tissue Specificity:
Isoform 2 expression is enhanced in testis.
Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 3 IQ domains.
Contains 1 Ras-GAP domain.
Contains 1 WW domain.
Database links:Entrez Gene: 10788 Human
Entrez Gene: 544963 Mouse
Omim: 605401 Human
SwissProt: Q13576 Human
SwissProt: Q3UQ44 Mouse
Unigene: 291030 Human
Unigene: 38878 Mouse
Unigene: 38878 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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