Product Name	Anti-HERC3/AF350
Chinese Name	AF350标记的HERC3 E3Ubiquitin蛋白连接酶抗体
Alias	HECT domain and RCC1 like domain containing protein 3; Hect domain and RLD 3; HERC 3; KIAA0032; Probable E3 ubiquitin protein ligase HERC3; HERC3_HUMAN.
Research Area	Cell biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	117kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HERC3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: HERC3 is a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Subcellular Location: Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures. Post-translational modifications: Ubiquitinated; which promotes degradation by the proteasome. Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 7 RCC1 repeats. Database links: UniProtKB/Swiss-Prot: Q15034.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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