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Product Name Anti-GPRC5C/AF350 Chinese Name AF350标记的G protein-coupled receptorGPRC5C蛋白抗体 Alias G-protein coupled receptor family C group 5 member; C; GPC5C; GPRC5C; MGC131820; PSEC0087; RAIG-3; RAIG3; Retinoic acid-induced gene 3 protein; GPC5C_HUMAN. Research Area Cell biology immunology Signal transduction G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 46kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GPRC5C Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPRC5C (G protein-coupled receptor, family C, group 5, member C), also known as RAIG3, is a 441 amino acid multi-pass membrane protein that localizes to cytoplasmic vesicles and belongs to the G protein-coupled receptor family. Expressed at high levels in stomach, liver, prostate, kidney and pancreas, GPRC5C is thought to function as a retinoic acid-inducible GPR that may play a role in signaling events throughout the cell. GPRC5C is subject to DNA damage-dependent phosphorylation, probably by ATM or ATR.
Function:
This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways (By similarity).
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.
Tissue Specificity:
Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).
Similarity:
Belongs to the G-protein coupled receptor 3 family.
Database links:Entrez Gene: 55890 Human
Entrez Gene: 70355 Mouse
Omim: 605949 Human
SwissProt: Q9NQ84 Human
SwissProt: Q8K3J9 Mouse
Unigene: 446438 Human
Unigene: 242413 Mouse
Unigene: 3658 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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