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Product Name Anti-CDX4/AF350 Chinese Name AF350标记的尾型同源盒转录因子4抗体 Alias Caudal-type homeobox protein 4; CDX4; CDX4_HUMAN; Homeobox protein CDX-4. Research Area Cell biology Stem cells Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 30kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from Human CDX4 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Cdx1, Cdx2 and Cdx4 are members of the caudal-type homeobox family of genes, which are homologs of the Drosophila “caudal” gene required for anterior-posterior regional identity. The proteins encoded by these genes are transcription factors which play an important role in development by regulating the expression of Hox genes. Hox genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. Cdx4 is a major positive regulator of the expression of all Hox family members. Due to its critical role as a regulator, Cdx4 is a direct target of the canonical Wnt pathway. The loss of Cdx4 can result in the development of an expanded hindbrain, while the overexpression of Cdx4 may cause the hindbrain to lose its distinct segmental features and resemble the spinal cord.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Caudal homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:Entrez Gene: 1046 Human
Entrez Gene: 12592 Mouse
Omim: 300025 Human
SwissProt: O14627 Human
SwissProt: Q07424 Mouse
Unigene: 553488 Human
Unigene: 4353 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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