Product Name	Anti-VGF/AF350
Chinese Name	AF350标记的神经内分泌调节肽VGF抗体
Alias	NERP-1; Nerve growth factor inducible; Neuroendocrine regulatory peptide-1; Neurosecretory protein VGF; VGF; VGF_HUMAN.
Research Area	Cell biology  Neurobiology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Guinea Pig, Danio rerio)
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	65kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NERP1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008] Function: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release. Subcellular Location: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus. Tissue Specificity: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. Post-translational modifications: Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure. Database links: Entrez Gene: 7425 Human Entrez Gene: 381677 Mouse Entrez Gene: 29461 Rat Omim: 602186 Human SwissProt: O15240 Human SwissProt: P20156 Rat Unigene: 587325 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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