Product Name	Anti-DEFA1/alpha Defensin 1/AF350
Chinese Name	AF350标记的防御素α1/3抗体
Alias	Defensin, alpha 1; alpha Defensin 1/3; alpha Defensin 1+3; ; Defensin alpha 3; HNP1; HNP3; HP1; DEF1_HUMAN; Neutrophil defensin 1; HNP-1; HP-1; HP1; HP 1-56; Neutrophil defensin 1; Neutrophil defensin 2; HNP-2; HP-2; HP2; DEFA1; DEF1; DEFA2; MRS; DEF3_HUMAN; Neutrophil defensin 3; Defensin, alpha 3; HNP-3; HP-3; HP3; HP 3-56;
Research Area	Cell biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	6.7kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human alpha Defensin 1/3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Defensins are a group of cyclic peptides containing 29-35 amino acids, which comprise approximately 30% of the total protein content of neutrophil azurophilic granules. Various functions have been reported for the defensins, including antibacterial and antifungal activity and chemotactic activity for monocytes. Function: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Subunit: Dimer. Subcellular Location: Secreted. Post-translational modifications: ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production. Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-rybosylation. Similarity: Belongs to the alpha-defensin family. Database links: Entrez Gene: 1667 Human Entrez Gene: 1668 Human Entrez Gene: 728358 Human Entrez Gene: 13216 Mouse Omim: 125220 Human SwissProt: P59665 Human SwissProt: P59666 Human SwissProt: P11477 Mouse Unigene: 380781 Human Unigene: 654448 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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