Product Name	Goat Anti-Mouse IgM / AF488
Chinese Name	Alexa Fluor 488标记的羊抗小鼠IgM
Alias	Goat Anti-Mouse IgM (Alexa Fluor® 488); Immunoglobulin M;
	Specific References  (6)     |     SL0368G-AF488 has been referenced in 6 publications. [IF=10.723] Jie Zhou. et al. Hyaluronic acid-based dual network hydrogel with sustained release of platelet-rich plasma as a diabetic wound dressing. CARBOHYD POLYM. 2023 Aug;314:120924  IF ;  Rat.   PubMed:37173024 [IF=8.679] Zhiyong Shen. et al. GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer. Cancer Lett. 2022 May;534:215617  IF ;  Human.   PubMed:35257833 [IF=7.367] Yitian Du. et al. Engineered Microglia Potentiate the Action of Drugs against Glioma Through Extracellular Vesicles and Tunneling Nanotubes. 2021 Feb 28  IF ;  Mouse.   PubMed:33644993 [IF=6.633] Li-Ming Yu. et al. Icariin attenuates excessive alcohol consumption-induced susceptibility to atrial fibrillation through SIRT3 signaling. BBA-MOL BASIS DIS. 2022 Oct;1868:166483  IF ;  Mouse.   PubMed:35798229 [IF=3.923] Yu M et al. Amino acids stimulate glycyl-tRNA synthetase nuclear localization for mammalian target of rapamycin expression in bovine mammary epithelial cells.(2018)J. Cell. Physiol.  IF ;  Mouse.   PubMed:30471104 [IF=3.89] Zhang, Minghui, et al. "Annexin A2 Positively Regulates Milk Synthesis and Proliferation of Bovine Mammary Epithelial Cells through the mTOR Signaling Pathway." Journal of Cellular Physiology (2017).  IF(ICC) ;  Mouse.   PubMed:28771726
Immunogen Species	Goat
Clonality	Polyclonal
React Species	Mouse,
Applications	Flow-Cyt=1:100-1000 IF=1:100-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Concentration	2.0 mg/ml
immunogen	Native Mouse IgM
Lsotype	IgG
Purification	affinity purified by Protein G
Buffer Solution	10 mM TBS (pH=7.4) with 1% BSA, 0.03% Proclin300 and 50% glycerol.
Storage	Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Product Detail	Immunoglobulin M (IgM) normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences.

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