Product Name	Angiopoietin 2
Chinese Name	血管生成素2重组兔单克隆抗体
Alias	AGPT 2; AGPT-2; Agpt2; ANG 2; ANG2; ANG-2; Angiopoietin 2a; Angiopoietin 2B; Angiopoietin2; Angiopoietin-2; ANGPT 2; ANGPT2; Tie2 ligand; ANGP2_HUMAN.
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	F5A4
React Species	(predicted: Rat, )
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	Secretory protein
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Angiopoietin 2
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Subunit: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. Subcellular Location: Secreted. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: O15123 Gene ID: 285 Database links: Entrez Gene: 285 Human Entrez Gene: 11601 Mouse Entrez Gene: 89805 Rat Omim: 601922 Human SwissProt: O15123 Human SwissProt: O35608 Mouse SwissProt: O35462 Rat Unigene: 583870 Human Unigene: 439874 Mouse Unigene: 138360 Rat 血管生成素2(angiopoietin-2, Ang-2)是Ang家族的成员之一,是特异性血管生成刺激因子,也是恶性Tumour早期的标志分子.

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